GSK3-B RECOMB BULK PACK SZ 250UG (C005B-095524)

General description

Glycogen synthase kinase 3β (GSK3β) is a serine-threonine kinase that is present in most eukaryotes. The GSK3β gene is located on the human chromosome at 3q13.3. GSK3β is made up of an N-terminal β-sheet domain that is coupled to the C-terminal α-helical domain.

Research area: Cell Signaling

Biochem/physiol Actions

Glycogen synthase kinase 3β (GSK3β) regulates glycogen metabolism via an insulin-dependent pathway. It participates in many signaling pathways including cellular processes such as cell cycle, cell proliferation, and inflammation. GSK3β mediated-negative regulation of insulin signaling pathway leads to type 2 diabetes. GSK3β functions as a tumor suppressor that represses neoplastic transformation in cells. It is an essential regulator of the Wnt/β-catenin signaling pathway. Abnormal regulation of GSK3β is associated with cardiovascular disease, bipolar disorder, and neurodegenerative diseases.

Packaging

Also available in 250μg size (2x125μg)--call for pricing and availability and reference catalog number 14-306M when ordering the 250μg size.

Quality

Routinely evaluated by phosphorylation of Phospho-Glycogen Synthase Peptide-2

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

biological source: human. Quality Level: 100. recombinant: expressed in baculovirus infected Sf21 cells. form: liquid. mol wt: M_w 51 . kDa. composition: mercaptoethanol, 0.1-1% , saccharose, 5-10% . manufacturer/tradename: Upstate^®. . storage condition: (Tightly closed). technique(s): activity assay: suitable (kinase). solubility: water: soluble. NCBI accession no.: NM_002093.2. UniProt accession no.: P49841. Gene Information: human ... GSK3B(2932). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H317. Precautionary Statements: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364. Hazard Classifications: Skin Sens. 1. Storage Class Code: 10 - Combustible liquids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.