GSK2194069 (C005B-312340)

Catalog No.: C005B-312340
Manufacturer No.: SML1259-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β:-ketoacyl reductase (KR) activity of hFAS with an IC 50 of 7.

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Description
Specifications

Biochem/physiol Actions

GSK2194069 is a fatty acid synthase (FAS) inhibitor. GSK2194069 is a potent and specific inhibitor of the β-ketoacyl reductase (KR) activity of hFAS with an IC₅₀ of 7.7 Â± 4.1 nM for the overall hFAS reaction. FAS is upregulated in some cancers, including prostate cancer. GSK2194069 was found to inhibit tumour growth in prostate cancer C42b cell xenografts generated in Nod-SCID-gamma mice. Cellular FAS inhibition reduced cell growth were also demonstrated in non-small-cell lung (A549) cancer cell lines with an average EC₅₀ of 15 Â± 0.5 nM.

UPC:: 12141605
Condition:: New
HazmatClass:: No
MPN:: SML1259-5MG
CAS:: 1332331-08-4

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