Product introductionGSK J1 is a potent and selective inhibitor of the histone H3 lysine 27 (H3K27) demethylase JMJD3, a Fe2+- and α-ketoglutarate-dependent oxygenase involved in a variety of physiological functions including the inflammatory response, with the half maximal inhibition concentration IC50 value of 60 nM .ApplicationGSK-J1 has been used in formaldehyde dehydrogenase (FDH)-coupled demethylase assay.
Specifications and Purity: 10mM in DMSO
Molecular Formula: C22H23N5O2
Molecular Weight: 389.46
PubChem CID: 56963315
Isomeric SMILES: C1CN(CCC2=CC=CC=C21)C3=NC(=NC(=C3)NCCC(=O)O)C4=CC=CC=N4
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/G421415-SCI_660ba598ef94dc85e30382798db044d9.pdf
- UPC:
- 10171605
- Condition:
- New
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- G421415-1ml
- CAS:
- 1373422-53-7
- Product Size:
- 1ml
- Hazard Statement Codes:
- H335:H319
- Precautionary Statement Codes:
- P280:P271:P264:P261
akash.verma@cenmed.com
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