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gsk'963 (c09-0902-339)

GSK'963 (C007B-173878)

Catalog No.
C007B-173878
Manufacturer No.
G422489-1ml
Manufacturer Name
Aladdin Scientific
Quantity
1
Unit of Measure
EA

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InformationGSK'963 GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >:10 000-fold selective for RIP1 over 339 other kinases.TargetsRIP1 kinase (Cell-free assay) 29 nMIn

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InformationGSK'963 GSK'963 is a chiral small-molecule inhibitor of RIP1 kinase (RIPK1) with an IC50 of 29 nM in FP binding assays. It is >10 000-fold selective for RIP1 over 339 other kinases.TargetsRIP1 kinase (Cell-free assay) 29 nMIn vitroGSK/'963 inhibits RIP1-dependent cell death with an IC50 of between 1 and 4/u2009nM in human and murine cells.In vivoGSK/'963 is a potent inhibitor of a TNF+zVAD-mediated lethal shock. At 2/u2009mg/kg, GSK/'963 would maintain blood concentrations above the concentration required for 90% inhibition of RIP1 activity for an extended period of time compared with Nec-1.Cell Research(from reference)Cell lines：BMDM Concentrations：100/u2009nM Incubation Time：30 min.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C14H18N2O

Molecular Weight: 230.31

PubChem CID: 122703613

Isomeric SMILES: CC(C)(C)C(=O)N1[C@@H](CC=N1)C2=CC=CC=C2

UPC:
10171605
Condition:
New
HazmatClass:
No
WeightUOM:
LB
MPN:
G422489-1ml
CAS:
2049868-46-2
Product Size:
1ml

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