GSK'843 (C005B-311347)

Catalog No.: C005B-311347
Manufacturer No.: SML2001-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions GSK′:843 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC 50 = 6.5 nM) with much reduced or little affinity toward 262 other kinases (IC 50 >:1 μ:M against 10 μ:M ATP in competitive binding

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Description
Specifications

Biochem/physiol Actions

GSK′843 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC₅₀ = 6.5 nM) with much reduced or little affinity toward 262 other kinases (IC₅₀ >1 μM against 10 μM ATP in competitive binding assay), including RIP5. GSK′843 effectively suppresses TNF/Z-VAD-FMK/IAP agonist treatment-induced necrosis induction in both human and murine cell cultures (EC₅₀ ranges from <0.12 to 3 μM), while inducing apoptosis in the absence of caspase inhibitor as a result of caspase 8 activation via RHIM-driven recruitment to assemble a Casp8-FADD-cFLIP complex independent of pronecrotic kinase activities and MLKL.

UPC:: 10161527
Condition:: New
HazmatClass:: No
MPN:: SML2001-5MG
CAS:: 1601496-05-2

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