GR-64349

Amino Acid Sequence

Lys-Asp-Ser-Phe-Val-Gly-R-γ-lactam-Leu-Met-NH2

General description

Neurokinin (NK) receptors are acted upon by tachykinins or neurokinins namely, NKA and NKB. These are endogenous ligands. An exogenous agonist/ligand for NK₂ is GR 64349 peptide.

Biochem/physiol Actions

GR 64349 peptide acts as an agonist of neurokinin (NK₂) receptor, which leads to reduced NK₂ response to kainate and AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid), but not to NMDA (N-methyl-D-aspartate).

Molecular Weight: 921.11. Empirical Formula: C₄₂H₆₈N₁₀O₁₁S. Quality Level: 200. Assay: >. 96%. storage temp.: −. 20°C. SMILES string: CSCC[C@H](NC(: O)[C@H](CC(C)C)N1CC[C@H](NC(: O)[C@@H](NC(: O)[C@H](Cc2ccccc2)NC(: O)[C@H](CO)NC(: O)[C@H](CC(O): O)NC(: O)[C@@H](N)CCCCN)C(C)C)C1: O)C(N): O. InChI: 1S/C42H68N10O11S/c1-23(2)19-32(40(61)46-27(35(45)56)15-18-64-5)52-17-14-28(42(52)63)47-41(62)34(24(3)4)51-38(59)29(20-25-11-7-6-8-12-25)49-39(60)31(22-53)50-37(58)30(21-33(54)55)48-36(57)26(44)13-9-10-16-43/h6-8,11-12,23-24,26-32,34,53H,9-10,13-22,43-44H2,1-5H3,(H2,45,56)(H,46,61)(H,47,62)(H,48,57)(H,49,60)(H,50,58)(H,51,59)(H,54,55)/t26-,27-,28-,29-,30-,31-,32-,34-/m0/s1. InChI key: HVUNRXRFMQDMBO-NOJSRKIXSA-N. Gene Information: human ... TACR2(6865)
mouse ... TACR2(21337)
rat ... TACR2(25007). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).