GNE-131 (C007B-358077)

Catalog No.: C007B-358077
Manufacturer No.: G654724-1ml
Manufacturer Name: Aladdin Scientific
Quantity: 1
Unit of Measure: EA

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Description
Specifications

GNE-131 is a potent and selective inhibitor of human sodium channel NaV1.7 , with an IC 50 of 3 nM.In VitroGNE-131 (Compound 13) shows moderate clearance in human liver microsomes and excellent functional activity against human NaV1.7 with an IC 50 of 0.003±0.001 μM. GNE-131 shows excellent potency, good in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoGNE-131 shows low in vivo clearance in mouse, rat, and dog. GNE-131 also displays excellent efficacy in a transgenic mouse model of induced pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:Na v 1.7 3 nM (IC 50 ).

Specifications and Purity: 10mM in DMSO

Molecular Formula: C23H30N4O3S

Molecular Weight: 442.57

UPC:: 41115710
Condition:: New
HazmatClass:: No
WeightUOM:: LB
MPN:: G654724-1ml
CAS:: 1629063-81-5
Product Size:: 1ml

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