GLYCINE ACS REAGENT >=98.5% (C005B-049038)

Application

Glycine has been used in whole-cell patch clamp recording to measure inward NMDA (N-methyl-D-aspartate) currents. It has also been used as a model organic system in crystallography to demonstrate a novel acoustic nebulization platform.

Biochem/physiol Actions

Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid.

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Molecular Weight: 75.07. Empirical Formula: C₂H₅NO₂. linearFormula: NH₂CH₂COOH. grade: ACS reagent. Quality Level: 200. Assay: ≥. 98.5%. form: powder, crystals or granules. impurities: H₂SO₄, passes test (darkened), Hydrolyzable subsances, passes test. ign. residue: ≤. 0.1%. color: white. pKa (25 °C): (1) 2.35, (2) 9.60, 2.35. mp: 240 . °C (dec.) (lit.). anion traces: chloride (Cl^-): ≤. 0.005%, sulfate (SO₄^2-): ≤. 0.005%. cation traces: NH₄⁺: ≤. 0.005%, heavy metals: ≤. 0.002% (by ICP). application(s): peptide synthesis. SMILES string: NCC(O): O. InChI: 1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5). InChI key: DHMQDGOQFOQNFH-UHFFFAOYSA-N. Gene Information: rat ... Grin2a(24409). Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).