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globomycin from streptomyces hagronensis

GLOBOMYCIN FROM STREPTOMYCES HAGRONENSIS

Catalog No.
C005B-056132
Manufacturer No.
G1424-1MG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
MG

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Globomycin is a cyclic peptide antibiotic, which inhibits the growth of enteric Gram-negative bacteria through cell wall synthesis inhibition. Biochem/physiol Actions Globomycin was found to inhibit LspA, a lipoprotein signal peptidase.

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General description

Globomycin is a cyclic peptide antibiotic, which inhibits the growth of enteric Gram-negative bacteria through cell wall synthesis inhibition.

Biochem/physiol Actions

Globomycin was found to inhibit LspA, a lipoprotein signal peptidase. It eliminates the maturation of pro-lipoproteins by inhibition of the enzyme that converts pro-lipoprotein to lipoprotein, acting as a substrate analog of the signal sequence in the outer membrane of Gram-negative bacteria.

Molecular Weight: 655.82. Empirical Formula: C32H57N5O9. biological source: Streptomyces hagronensis. Quality Level: 200. Assay: ≥. 98% (HPLC). form: powder. color: white. solubility: DMSO: 1 . mg/mL. antibiotic activity spectrum: Gram-negative bacteria. Mode of action: enzyme | inhibits. storage temp.: −. 20°C, −. 20°C. InChI: 1S/C32H57N5O9/c1-9-11-12-13-14-24-20(6)32(45)37(8)23(15-18(3)4)29(42)35-26(19(5)10-2)31(44)34-22(17-38)28(41)36-27(21(7)39)30(43)33-16-25(40)46-24/h18-24,26-27,38-39H,9-17H2,1-8H3,(H,33,43)(H,34,44)(H,35,42)(H,36,41). InChI key: VFGBXFZXJAWPOE-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.
UPC:
41106210
Condition:
New
HazmatClass:
No
MPN:
G1424-1MG
CAS:
67076-74-8

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