GL0388 (C007B-358321)

GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC 50 s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis . GL0388 supAppearance:SolidIC50& Target:BaxIn Vitro:GL0388 (0.1-10 μM; 72 h) inhibits the cell proliferation of MDA-MB-231 and MCF-7 breast cancer cell lines, with IC 50 s of 0.96 μM and 0.52 μM, respectively. GL0388 (0.01-100 μM) inhibits the cell proliferation in 60 human tumor cell lines, with GI5In Vivo:GL0388 (10-20mg/kg for i.p.; 15mg/kg for i.t.; once daily for 10 days) dose-dependently suppresses the growth of MDA-MB-231 tumors in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal ModelBiological Activity:GL0388 is a Bax activator that results in Bax insertion into mitochondrial membrane. GL0388 shows antiproliferative activities against various cancer cells, with IC 50 s of 0.299-1.57 μM. GL0388 activates Bax and induce Bax-mediated apoptosis . GL0388 sup.

Specifications and Purity: ≥98%

Molecular Formula: C21H17FN2O

Molecular Weight: 332.37