Biochem/physiol Actions GKA50 is a specific activator of glucokinase (EC 50 = 0.03 μ:M).
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GKA50 is a specific activator of glucokinase (EC50 = 0.03 μM). In mouse MIN6 insulin-secreting cells and rat pancreatic islet cells, GKA50 elicits a leftward shift in response to sub-maximal glucose concentrations as measured by insulin secretion and elevation of intracellular calcium levels.
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