GI254023X (C005B-312958)

Catalog No.: C005B-312958
Manufacturer No.: SML0789-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Application GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10). Biochem/physiol Actions GI254023X blocks ADAM10 (ADAM metallopeptidase domain 10) activity and decreases human leukocyte antigen (HLA)-mediated

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Description
Specifications

Application

GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10).

Biochem/physiol Actions

GI254023X blocks ADAM10 (ADAM metallopeptidase domain 10) activity and decreases human leukocyte antigen (HLA)-mediated cytotoxicity and cleavage of extracellular E-cadherin in epithelial and endothelial cells.

GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). In a study using recombinant TACE and ADAM10 ectodomain, the IC₅₀ for GI254023X was 5.3 nM for ADAM10 vs 541 nM for TACE.

GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor.

UPC:: 42202202
Condition:: New
HazmatClass:: No
MPN:: SML0789-25MG
CAS:: 260264-93-5

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