GDF-15 HUMAN RECOMBINANT

General description

Growth-differentiation factor-15 (GDF-15) is a stress-responsive member of the transforming growth factor-β cytokine superfamily. It is also known as PTGF-Growth-differentiation factor-15 (GDF-15) and is a stress-responsive member of the transforming growth factor-β cytokine superfamily.² It is also known as PTGF-β, TGF-PL or MIC-1β, TGF-PL or MIC-1.

Application

Growth-differentiation factor-15 (GDF-15) has been associated in the regulation of cell survival, proliferation, and differentiation and also in the protection from ischemia/reperfusion injury. Inflammatory and apoptotic pathways are regulated in injured tissues by GDFs during disease processes.

Biochem/physiol Actions

Although it has been classified as a divergent member of the transforming growth factor-β superfamily, GDF-15 shares structural characteristics with this superfamily. It has been identified as a biomarker for human prostate cancer. Additionally, increased GDF-15 expression has been observed in breast, pancreas and colorectal cancers. Functions of this cytokine include inhibition of TNF-α production, initiation of cartilage formation, and promotion of neuronal survival.
It has been discussed to serve as a secreted biomarker for activation of the p53 pathway in human cancer.

Physical form

Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile, 0.1% trifluoroacetic acid containing 50 μg of bovine serum albumin per 1 μg of GDF-15.

Analysis Note

Under reducing conditions in SDS-PAGE, each recombinant GDF-15 monomer migrates as an ~14 kDa protein.

biological source: human. Quality Level: 100. recombinant: expressed in CHO cells. Assay: >. 97% (visualized with silver stain, SDS-PAGE). form: lyophilized powder. mol wt: dimer 13 . kDa (based on N-terminal sequencing, starting at the first histidine of the 6X histidine tag). technique(s): cell culture | mammalian: suitable. impurities: endotoxin, tested. UniProt accession no.: Q99988. storage temp.: −. 20°C. Gene Information: human ... GDF15(9518). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.