GALANTHAMINE HYDROBROMIDE >= 94% (HPLC) (C005B-000007)

General description

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).

Application

Galanthamine hydrobromide from Lycoris sp. has been used-

• as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE
• as a positive control in the screening of AChE inhibitors
• as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides

Biochem/physiol Actions

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Molecular Weight: 368.27. Empirical Formula: C₁₇H₂₁NO₃ · HBr. biological source: plant (Ungeria victoris). Quality Level: 100. Assay: ≥. 94% (HPLC). form: powder. mp: 270 . °C. solubility: DMSO: soluble 10 . mg/mL, clear, colorless, water: soluble 20 . mg/mL, clear, colorless. storage temp.: −. 20°C. SMILES string: Br[H].COc1ccc2CN(C)CC[C@@]34C: C[C@H](O)C[C@@H]3Oc1c24. InChI: 1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17. /h3-6,12,14,19H,7-10H2,1-2H3. 1H/t12-,14-,17-. /m0./s1. InChI key: QORVDGQLPPAFRS-XPSHAMGMSA-N. Gene Information: human ... ACHE(43). Pictograms: GHS06. Signal Word: Danger. Hazard Statements: H301. Precautionary Statements: P301 + P310. Hazard Classifications: Acute Tox. 3 Oral. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges.