Amino Acid Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-His-Ala-Val-Gly-Asn-His-Arg-Ser-Phe-Ser-Asp-Lys-Asn-Gly-Leu-Thr-Ser

General description

Galanin (GAL) is a neuropeptide composed of 29 amino acids. It has wide range of expression in central and peripheral nervous system. It acts as a ligand for three G-protein coupled receptor (GPCR) subtypes called GalR1, GalR2 and GalR3.

Application

Galanin human has been used in immunohistochemistry performed on ileums of pigs to study the effect of the mycotoxin zearalenone on the expression of intestinal peptides.

Biochem/physiol Actions

Galanin (GAL) is involved in multiple physiological actions such as, nociception, cognition, memory, hunger, hormone and neurotransmitter release, and cell growth. It also controls the release of gastric acid, plays a role in the contraction of intestines, and suppresses the secretion of pancreatic peptides. This peptide is up-regulated in colorectal cancer (CRC), which relates to aggressive phenotype and poor prognosis of patients with stage II CRC. Studies in Chinese Han female population show that polymorphisms in this gene are linked to susceptibility to depression.

Other Notes

Lyophilized from 0.1% TFA in H2O

Molecular Weight: 3157.41. Empirical Formula: C₁₃₉H₂₁₀N₄₂O₄₃. Quality Level: 200. Assay: ≥. 97% (HPLC). form: powder. composition: Peptide content, ≥. 70% . UniProt accession no.: P22466. storage temp.: −. 20Â°C. SMILES string: CC(C)C[C@H](NC(: O)CNC(: O)[C@H](CC(N): O)NC(: O)[C@H](CCCCN)NC(: O)[C@H](CC(O): O)NC(: O)[C@H](CO)NC(: O)[C@H](Cc1ccccc1)NC(: O)[C@H](CO)NC(: O)[C@H](CCCNC(N): N)NC(: O)[C@H](Cc2c[nH]cn2)NC(: O)[C@H](CC(N): O)NC(: O)CNC(: O)[C@@H](NC(: O)[C@H](C)NC(: O)[C@H](Cc3c[nH]cn3)NC(: O)[C@@H]4CCCN4C(: O)CNC(: O)[C@H](CC(C)C)NC(: O)[C@H](CC(C)C)NC(: O)[C@H](Cc5ccc(O)cc5)NC(: O)CNC(: O)[C@H](C)NC(: O)[C@H](CO)NC(: O)[C@H](CC(N): O)NC(: O)[C@H](CC(C)C)NC(: O)[C@@H](NC(: O)[C@H](Cc6c[nH]c7ccccc67)NC(: O)CN)[C@@H](C)O)C(C)C)C(: O)N[C@@H]([C@@H](C)O)C(: O)N[C@@H](CO)C(O): O. InChI: 1S/C139H210N42O43/c1-65(2)38-84(165-121(206)86(40-67(5)6)166-123(208)88(43-75-31-33-79(188)34-32-75)161-106(193)55-151-114(199)70(11)157-131(216)97(59-182)175-127(212)95(49-104(144)191)170-122(207)87(41-68(7)8)173-136(221)112(72(13)186)180-130(215)90(159-105(192)51-141)44-76-52-150-81-27-19-18-26-80(76)81)116(201)154-58-109(196)181-37-23-30-101(181)134(219)172-91(45-77-53-147-63-155-77)120(205)158-71(12)115(200)178-111(69(9)10)135(220)153-57-108(195)162-94(48-103(143)190)126(211)168-92(46-78-54-148-64-156-78)125(210)164-83(29-22-36-149-139(145)146)119(204)174-98(60-183)132(217)167-89(42-74-24-16-15-17-25-74)124(209)176-99(61-184)133(218)171-96(50-110(197)198)128(213)163-82(28-20-21-35-140)118(203)169-93(47-102(142)189)117(202)152-56-107(194)160-85(39-66(3)4)129(214)179-113(73(14)187)137(222)177-100(62-185)138(223)224/h15-19,24-27,31-34,52-54,63-73,82-101,111-113,150,182-188H,20-23,28-30,35-51,55-62,140-141H2,1-14H3,(H2,142,189)(H2,143,190)(H2,144,191)(H,147,155)(H,148,156)(H,151,199)(H,152,202)(H,153,220)(H,154,201)(H,157,216)(H,158,205)(H,159,192)(H,160,194)(H,161,193)(H,162,195)(H,163,213)(H,164,210)(H,165,206)(H,166,208)(H,167,217)(H,168,211)(H,169,203)(H,170,207)(H,171,218)(H,172,219)(H,173,221)(H,174,204)(H,175,212)(H,176,209)(H,177,222)(H,178,200)(H,179,214)(H,180,215)(H,197,198)(H,223,224)(H4,145,146,149)/t70-,71-,72+,73+,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,111-,112-,113-/m0/s1. InChI key: CBSXZYWGVAQSHI-RUKUCZSXSA-N. Gene Information: human ... GAL(51083). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).