FMOC-LYS(MMT)-OH 1 G

General description

An excellent derivative for the synthesis by Fmoc SPPS of branched peptides and peptides modified at the lysine side-chain ^[1], and for the construction of templates and multifunctionalized resins for combinatorial synthesis.The side-chain Mmt group can be selectively removed in the same manner as Mtt with 1% TFA in DCM ^[2,3,4] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) ^[5]. Alternatively, it can be removed under milder conditions with AcOH/TFE/DCM (1:2:7) ^[1], leaving Mtt intact.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] S. Matysiak, et al. (1998) Tetrahedron Lett., 39, 1733.
^[2] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283.
^[3] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488.
^[4] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264.
^[5] K. Barlos, personal communication.

Linkage

Replaces: 04-12-1232

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Enantiomeric purity: ≥ 99.0 % (a/a)
Purity (TLC(0009)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Assay (acidimetric): ≥ 80.0 %
Water (K. F.): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.
Product is stabilised with up to 20% diisopropylether upon drying.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 640.77. Empirical Formula: C₄₁H₄₀N₂O₅. Quality Level: 200. product line: Novabiochem^®. . Assay: ≥. 80.0% (acidimetric), ≥. 95% (TLC), ≥. 95.0% (HPLC). form: powder. reaction suitability: reaction type: Fmoc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem^®. . application(s): peptide synthesis. functional group: amine. storage temp.: 2-8°C. InChI: 1S/C41H40N2O5/c1-47-32-25-23-31(24-26-32)41(29-14-4-2-5-15-29,30-16-6-3-7-17-30)42-27-13-12-22-38(39(44)45)43-40(46)48-28-37-35-20-10-8-18-33(35)34-19-9-11-21-36(34)37/h2-11,14-21,23-26,37-38,42H,12-13,22,27-28H2,1H3,(H,43,46)(H,44,45)/t38-/m0/s1. InChI key: CTYHQVFFQRDJSN-LHEWISCISA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.