FMOC-DPR(MTT)-OH 5 G

General description

The side-chain Mtt group can be selectively removed with 1% TFA in DCM ^[1,2,3] or DCM/HFIP/TFE/TES (6.5:2:1:0.5) ^[4], making this an excellent derivative for the synthesis of branched peptides and peptides modified at the Dpr side-chain ^[4,5], and for the construction of templates and multifunctionalized resins for combinatorial synthesis^[6].

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS

Literature references

^[1] K. Barlos, et al., C. H. Schneider & A. N. Eberle (Eds), ESCOM, Leiden, 1993, pp. 283.
^[2] A. Aletras, et al. (1995) Int. J. Peptide Protein Res., 45, 488.
^[3] L. Bourel, et al. (2000) J. Peptide Sci., 6, 264.
^[4] K. Barlos, personal communication.
^[5] P. Hoogerhout, et al. (1999) J. Peptide Res., 54, 436.
^[6] C. Park & K. Burgess (2001) J. Comb. Chem., 3, 257.

Linkage

Replaces: 04-12-1204

Analysis Note

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): +10.0 - +13.0 °
Purity (TLC(157A)): ≥ 95 %
Assay (HPLC, area%): ≥ 95.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

Legal Information

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

Molecular Weight: 582.69. Empirical Formula: C₃₈H₃₄N₂O₄. Quality Level: 200. product line: Novabiochem^®. . Assay: ≥. 95% (TLC), ≥. 95.0% (HPLC). form: powder. reaction suitability: reaction type: Fmoc solid-phase peptide synthesis. manufacturer/tradename: Novabiochem^®. . application(s): peptide synthesis. functional group: amine. storage temp.: 15-25°C. InChI: 1S/C38H34N2O4/c1-26-20-22-29(23-21-26)38(27-12-4-2-5-13-27,28-14-6-3-7-15-28)39-24-35(36(41)42)40-37(43)44-25-34-32-18-10-8-16-30(32)31-17-9-11-19-33(31)34/h2-23,34-35,39H,24-25H2,1H3,(H,40,43)(H,41,42)/t35-/m0/s1. InChI key: WDZDBCVDBMWMAM-DHUJRADRSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Flash Point(F): Not applicable. Flash Point(C): Not applicable.