FLUTAMIDE (C005B-015250)

Application

Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro. It has also been used to study the effects of flutamide on anogenital distance and nipple retention.

Biochem/physiol Actions

Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of testosterone and dihydrotestosterone receptors. It is a potent hepatotoxin.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 276.21. Empirical Formula: C₁₁H₁₁F₃N₂O₃. Quality Level: 100. originator: Schering Plough. SMILES string: CC(C)C(: O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-]): O. InChI: 1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17). InChI key: MKXKFYHWDHIYRV-UHFFFAOYSA-N. Gene Information: human ... AR(367)
mouse ... Ar(11835)
rat ... Ar(24208). Pictograms: GHS07,GHS08,GHS09. Signal Word: Warning. Hazard Statements: H302 - H351 - H361 - H373 - H411. Precautionary Statements: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2. Target Organs: Liver. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges.