Fluprostenol (C007B-170003)

Fluprostenol is a PGF|2α|R (prostaglandin F (FP) receptor) agonist that is more selective than PGF|2α|. The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK|3|(c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca|+|mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.

Specifications and Purity: ≥96%

Molecular Formula: C23H29F3O6

Molecular Weight: 458.47

EC Number: 200-578-6

PubChem CID: 5311100

Isomeric SMILES: C1[C@@H]([C@@H]([C@H]([C@@H]1O)/C=C/[C@H](COC2=CC=CC(=C2)C(F)(F)F)O)C/C=C/CCCC(=O)O)O