FIBRINOPEPTIDE A (C005B-027923)

Amino Acid Sequence

Ala-Asp-Ser-Gly-Glu-Gly-Asp-Phe-Leu-Ala-Glu-Gly-Gly-Gly-Val-Arg

General description

Fibrinopeptide A (FPA) is produced from the N-terminal Aα region of fibrinogen protein, on cleavage by thrombin. It is composed of 16 amino acids.

Application

Fibrinopeptide A human has been used for protein control experiments performed during sandwich ELISA microarray assay to distinguish between plasma and serum fibrinogen samples. It has also been used in a peptide mixture along with BSA (bovine serum albumin) to ascertain the relation between fragmentation voltage and peptide ion drift time for IMS-MS (ion mobility spectrometry coupled with mass spectrometry).

Biochem/physiol Actions

Fibrinogen plays essential roles in coagulation of blood, wound healing, platelet aggregation and has roles in various other physiological processes. Increase in the levels of fibrinopeptide A (FPA) is found in multiple disorders such as coronary artery disease, disseminated intravascular coagulation, arterial thrombosis, deep venous thrombosis and cancers.

Molecular Weight: 1536.56. Empirical Formula: C₆₃H₉₇N₁₉O₂₆. biological source: human. Quality Level: 200. Assay: ≥. 96% (HPLC). form: powder. technique(s): ELISA: suitable, mass spectrometry (MS): suitable. UniProt accession no.: P02671. storage temp.: −. 20°C. SMILES string: CC(C)CC(NC(: O)C(Cc1ccccc1)NC(: O)C(CC(O): O)NC(: O)CNC(: O)C(CCC(O): O)NC(: O)CNC(: O)C(CO)NC(: O)C(CC(O): O)NC(: O)C(C)N)C(: O)NC(C)C(: O)NC(CCC(O): O)C(: O)NCC(: O)NCC(: O)NCC(: O)NC(C(C)C)C(: O)NC(CCCNC(N): N)C(O): O. InChI: 1S/C63H97N19O26/c1-29(2)19-37(57(102)73-32(6)53(98)76-35(15-17-48(91)92)55(100)70-24-43(85)68-23-42(84)69-25-46(88)82-51(30(3)4)61(106)77-36(62(107)108)13-10-18-67-63(65)66)79-58(103)38(20-33-11-8-7-9-12-33)80-59(104)39(21-49(93)94)75-45(87)27-71-54(99)34(14-16-47(89)90)74-44(86)26-72-56(101)41(28-83)81-60(105)40(22-50(95)96)78-52(97)31(5)64/h7-9,11-12,29-32,34-41,51,83H,10,13-28,64H2,1-6H3,(H,68,85)(H,69,84)(H,70,100)(H,71,99)(H,72,101)(H,73,102)(H,74,86)(H,75,87)(H,76,98)(H,77,106)(H,78,97)(H,79,103)(H,80,104)(H,81,105)(H,82,88)(H,89,90)(H,91,92)(H,93,94)(H,95,96)(H,107,108)(H4,65,66,67). InChI key: JWICNZAGYSIBAR-UHFFFAOYSA-N. Gene Information: human ... FGA(2243). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).