EVEROLIMUS-D4100¡?G/ML IN ACETONITRILE AMPULE OF 1¡ML CERTIFIED REFERENCE MATERIAL CERILLIANT

General description

A stable-labeled internal standard for the immunosuppressant Everolimus, marketed as Zortress^® and Certican for use in organ transplantation and Afinitor^® for treatment of kidney and pancreatic cancers. Clinical laboratories quantitate everolimus levels in patient whole blood samples using LC-MS/MS. While many everolimus LC-MS/MS methods use 32-desmethoxyrapamycin or ascomycin as an internal standard, higher levels of variability / lower levels of reproducibility may occur in the analysis along with the potential for interferences. Use of a stable-labeled analog of everolimus is the best choice to minimize variability or mitigate any potential interference in LC-MS/MS analysis.

Legal Information

Afinitor is a registered trademark of Novartis AG

CERILLIANT is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Cerilliant Corporation

Zortress is a registered trademark of Novartis AG

Molecular Weight: 962.25. Empirical Formula: C₅₃H₇₉NO₁₄D₄. grade: certified reference material. Quality Level: 300. form: liquid. feature: Snap-N-Spike^®. /Snap-N-Shoot^®. . packaging: ampule of 1 . mL. manufacturer/tradename: Cerilliant^®. . concentration: 100 . μ. g/mL in acetonitrile. technique(s): gas chromatography (GC): suitable, liquid chromatography (LC): suitable. application(s): clinical testing. format: single component solution. storage temp.: −. 70°C. SMILES string: [2H]C([2H])(O)C([2H])([2H])OC1CCC(CC(C)C2CC(: O)C(C)\C: C(C)\C(O)C(OC)C(: O)C(C)CC(C)\C: C\C: C\C: C(C)\C(CC3CCC(C)C(O)(O3)C(: O)C(: O)N4CCCCC4C(: O)O2)OC)CC1OC. InChI: 1S/C53H83NO14/c1-32-16-12-11-13-17-33(2)44(63-8)30-40-21-19-38(7)53(62,68-40)50(59)51(60)54-23-15-14-18-41(54)52(61)67-45(35(4)28-39-20-22-43(66-25-24-55)46(29-39)64-9)31-42(56)34(3)27-37(6)48(58)49(65-10)47(57)36(5)26-32/h11-13,16-17,27,32,34-36,38-41,43-46,48-49,55,58,62H,14-15,18-26,28-31H2,1-10H3/b13-11+,16-12+,33-17+,37-27+/i24D2,25D2. InChI key: HKVAMNSJSFKALM-ULVVDLMCSA-N. Pictograms: GHS02,GHS07. Signal Word: Danger. Hazard Statements: H225 - H302 + H312 + H332 - H319. Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2. Storage Class Code: 3 - Flammable liquids. WGK: WGK 2. Flash Point(F): 35.6 °F - closed cup. Flash Point(C): 2 °C - closed cup.