ETP-46464

Catalog No.: C005B-312267
Manufacturer No.: SML1321-5MG
Manufacturer Name: Sigma-Aldrich
Quantity: 5
Unit of Measure: MG

Biochem/physiol Actions ETP-46464 is a potent and selective inhibitor of the DNA damage response kinase Ataxia telangiectasia-mutated (ATM) - and Rad3-related (ATR) with an IC 50 of 25 nM. ETP-46464 shows moderate activity against PI3K and is a

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Description
Specifications

Biochem/physiol Actions

ETP-46464 is a potent and selective inhibitor of the DNA damage response kinase Ataxia telangiectasia-mutated (ATM) - and Rad3-related (ATR) with an IC₅₀of 25 nM. ETP-46464 shows moderate activity against PI3K and is a potent inhibitor of mTor, but is selective for ATR versus ATM and DNA -dependent protein kinase (DNA -PKcs) even at high doses. ETP-46464 inhibited phosphorylation of Chk1, the downstream kinase of ATR, but did not affect ionizing radiationâ€“induced γH2AX formation, which is jointly controlled by ATM and DNA-PKc.

UPC:: 41106403
Condition:: New
HazmatClass:: No
MPN:: SML1321-5MG
CAS:: 1345675-02-6

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