β-Estradiol 17-(β-D-glucuronide) sodium salt (C007B-153405)

β-Estradiol 17-(β-D-glucuronide) sodium salt is a glucocorticosteroid estrogen metabolite formed in the liver, and excreted in bile. β-Estradiol 17-(β-D-glucuronide) sodium salt functions as a substrate of the multidrug resistance protein 2 (MRP2), and with its cholestatic agentry, β-Estradiol 17-(β-D-glucuronide) sodium salt can actually decrease bile flow. After binding to the MRP2 site, β-Estradiol 17-(β-D-glucuronide) sodium salt has been shown to bind to an allosteric site that activates its own transport via MRP2, and the transport of other MRP2 substrates including non-cholestatic estrogen metabolites. β-Estradiol 17-(β-D-glucuronide) sodium salt has also been observed being transported by MDR1, MRP1, MRP3, MRP4, MRP7, ABCG2, and rat organic anion-transporting polypeptides 1-4.

Specifications and Purity: ≥95%

Molecular Formula: C24H31O8·Na[XH2O]

Molecular Weight: 470.5(anhydrous)

PubChem CID: 86290017

Isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)C(=O)[O-])O)O)O)CCC5=C3C=CC(=C5)O.[Na+]

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/E337172-SCI_0b06aee9ae3bf1e2a852d0346a43b5a1.pdf