EQUILIN (C005B-041433)

Biochem/physiol Actions

Equilin is the Mare estrogen and is majorly used in multi-estrogen drugs for hormone replacement therapy. It is synthesized in the microsomes of mare placenta. It mediates estrogen receptor β (ERβ) expression resulting in the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) which favors monocytes adhesion in atherosclerosis. In vitro equilin inhibits 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) that catalyzes the conversion of estrone to 17β-estradiol.

Molecular Weight: 268.35. Empirical Formula: C₁₈H₂₀O₂. biological source: synthetic (organic). Quality Level: 100. sterility: non-sterile. Assay: ≥. 98% (HPLC). form: powder. technique(s): inhibition assay: suitable. mp: 238-240 . °C (lit.). solubility: chloroform: methanol (1:1): 40 . mg/mL, clear, colorless to faintly yellow. shipped in: ambient. storage temp.: room temp. SMILES string: C[C@]12CC[C@H]3C(: CCc4cc(O)ccc34)[C@@H]1CCC2: O. InChI: 1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16,19H,2,6-9H2,1H3/t14-,16+,18+/m1/s1. InChI key: WKRLQDKEXYKHJB-HFTRVMKXSA-N. Pictograms: GHS08. Signal Word: Warning. Hazard Statements: H351 - H361fd - H362. Precautionary Statements: P202 - P260 - P263 - P264 - P270 - P308 + P313. Hazard Classifications: Carc. 2 - Lact. - Repr. 2. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges.