EPIRUBICIN HYDROCHLORIDE (C005B-049009)

Application

Epirubicin is used to inhibit topoisomerase II and DNA helicase activity. Epirubicin is used to study metastatic breast cancerand cardiac toxicity.

Biochem/physiol Actions

Epirubicin is antimitotic and cytotoxic. It inhibits nucleic acid and protein synthesis. Epirubicin may do so by forming complexes with DNA and intercalation between base pairs, by inhibiting topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, and by preventing the religation portion of the ligation-religation reaction that topoisomerase II catalyzes.

Cell-permeable anthracycline antitumor antibiotic. Antineoplastic. A stereoisomer of doxorubicin that exhibits reduced cardiotoxicity. Its antitumor actions are mediated by targeting topoisomerase II.

Molecular Weight: 579.98. Empirical Formula: C₂₇H₂₉NO₁₁ · HCl. biological source: synthetic. Quality Level: 100. Assay: ≥. 90% (HPLC). form: powder. color: red to deep red. solubility: H₂O: soluble. antibiotic activity spectrum: neoplastics. Mode of action: DNA synthesis | interferes, enzyme | inhibits. storage temp.: −. 20°C. SMILES string: Cl.COc1cccc2C(: O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@@H](O)[C@H](C)O5)c4c(O)c3C(: O)c12)C(: O)CO. InChI: 1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34. /h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3. 1H/t10-,13-,15-,17-,22-,27-. /m0./s1. InChI key: MWWSFMDVAYGXBV-FGBSZODSSA-N. Pictograms: GHS07,GHS08. Signal Word: Danger. Hazard Statements: H302 - H340 - H350 - H360. Precautionary Statements: P201 - P301 + P312 + P330 - P308 + P313. Hazard Classifications: Acute Tox. 4 Oral - Carc. 1B - Muta. 1B - Repr. 1B. Storage Class Code: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects. WGK: WGK 3. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.