ENALAPRIL MALEATE (C005B-077603)

General description

Enalapril is an angiotensin-converting enzyme inhibitor. It is used to treat heart failure and high blood pressure.

Application

Enalapril maleate salt has been used:

• to reduce albumin excretion rate (AER) and glomerular lesions
• to examine the effects of enalapril pre-treatment on myocardial injury
• to investigate its efficacious doses and schedules for mitigation of radiation lung injury

Biochem/physiol Actions

A long-acting angiotensin-converting enzyme inhibitor.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Molecular Weight: 492.52. Empirical Formula: C₂₀H₂₈N₂O₅ · C₄H₄O₄. Quality Level: 100. Assay: ≥. 98% (TLC). form: powder. color: white to off-white. solubility: methanol: ≥. 50 . mg/mL, clear, colorless to yellow. originator: Merck &. Co., Inc., Kenilworth, NJ, U.S.. SMILES string: C[C@@H](C(N1[C@H](C(O): O)CCC1): O)N[C@H](CC(OCC): O)CCC2: CC: CC: C2.O: C(OO)/C: C\C(O): O. InChI: 1S/C21H30N2O5.C4H4O5/c1-3-28-19(24)14-17(12-11-16-8-5-4-6-9-16)22-15(2)20(25)23-13-7-10-18(23)21(26)27. 5-3(6)1-2-4(7)9-8/h4-6,8-9,15,17-18,22H,3,7,10-14H2,1-2H3,(H,26,27). 1-2,8H,(H,5,6)/b. 2-1-/t15-,17-,18-. /m0./s1. InChI key: UQKQUZOIQFOJOI-KJHLASMFSA-N. Pictograms: GHS08. Signal Word: Warning. Hazard Statements: H361fd. Precautionary Statements: P201 - P202 - P280 - P308 + P313 - P405 - P501. Hazard Classifications: Repr. 2. Storage Class Code: 11 - Combustible Solids. WGK: WGK 2. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).