Elimusertib (BAY-1895344) (C007B-154919)

InformationElimusertib (BAY-1895344) is a very potent and highly selectiveATR (ataxia telangiectasia and Rad3-related)inhibitor with IC50 of 7 nM. Elimusertib potently inhibits proliferation of a broad spectrum of human tumor cell lines with median IC50 of 78 nM.TargetsATR (Cell-free assay) 7 nMIn vitroBAY-1895344 inhibits tumor cell growth and viability and exhibits potent antiproliferative activity in a broad spectrum of human tumor cell lines.In vivoBAY 1895344 exhibits strong monotherapy efficacy in cancer xenograft models that carry DNA damage repair deficiencies.Cell Research(from reference)Cell lines：HT-29 cells, M059J cells, 38 cancer cell lines Concentrations：3–300 nM Incubation Time：72 to 96 hours.

Specifications and Purity: ≥98%

Molecular Formula: C20H21N7O

Molecular Weight: 375.43

PubChem CID: 118869362

Isomeric SMILES: C[C@@H]1COCCN1C2=NC3=C(C=CN=C3C4=CC=NN4)C(=C2)C5=CC=NN5C

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