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elacridar (c15-1725-162)

ELACRIDAR (C005B-313325)

Catalog No.
C005B-313325
Manufacturer No.
SML0486-50MG
Manufacturer Name
Sigma-Aldrich
Quantity
50
Unit of Measure
MG

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Application Elacridar has been used: as a chemical to decipher the link between autophagy and the mechanism of resistance to sunitinib as an ATP-binding cassette sub-family B member 1 inhibitor to study its effects on the NSC23766 cytotoxicity

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Application

Elacridar has been used:

  • as a chemical to decipher the link between autophagy and the mechanism of resistance to sunitinib
  • as an ATP-binding cassette sub-family B member 1 inhibitor to study its effects on the NSC23766 cytotoxicity
  • to treat rhodamine 123 (Rh123) labeled cells to set sorting gates in fluorescence-activated cell sorting (FACS)

Biochem/physiol Actions

GF120918 (Elacridar) is a very potent inhibitor of the ABC transporters MDR-1 (P-gp) and BCRP. GF120918 increases the bioavailability of cytotoxic anti-tumor drugs, and also leads to increased levels of anti-HIV drugs in the brain and CNS.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

UPC:
41114502
Condition:
New
HazmatClass:
No
MPN:
SML0486-50MG
CAS:
143664-11-3
Temperature Control Device:
Yes

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