DYNORPHIN A PORCINE (C005B-081459)

Amino Acid Sequence

Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln

Application

Dynorphin A has been used in immunohistochemistry.

Biochem/physiol Actions

Dynorphin A porcine is an opioid peptide. It is an endogenous κ-agonist that is resistant to enzymatic degradation. Dynorphin A has the ability to decrease calcium current by selectively decreasing the large inactivating (N) calcium current. It can decrease the calcium-dependent action potential duration of DRG (dorsal root ganglion) and myenteric neurons.

Molecular Weight: 2147.48. Empirical Formula: C₉₉H₁₅₅N₃₁O₂₃. Quality Level: 200. Assay: ≥. 95% (HPLC). form: powder. UniProt accession no.: P01214, P32300, P33533, P41145. storage temp.: −. 20°C. SMILES string: [H]N[C@@H](Cc1ccc(O)cc1)C(: O)NCC(: O)NCC(: O)N[C@@H](Cc2ccccc2)C(: O)N[C@@H](CC(C)C)C(: O)N[C@@H](CCCNC(N): N)C(: O)N[C@@H](CCCNC(N): N)C(: O)N[C@@H]([C@@H](C)CC)C(: O)N[C@@H](CCCNC(N): N)C(: O)N3CCC[C@H]3C(: O)N[C@@H](CCCCN)C(: O)N[C@@H](CC(C)C)C(: O)N[C@@H](CCCCN)C(: O)N[C@@H](Cc4c[nH]c5ccccc45)C(: O)N[C@@H](CC(O): O)C(: O)N[C@@H](CC(N): O)C(: O)N[C@@H](CCC(N): O)C(O): O. InChI: 1S/C99H155N31O23/c1-7-55(6)81(129-86(142)66(28-18-40-112-98(107)108)118-83(139)65(27-17-39-111-97(105)106)120-88(144)70(44-54(4)5)125-89(145)71(46-56-21-9-8-10-22-56)117-79(135)52-115-78(134)51-116-82(138)61(102)45-57-31-33-59(131)34-32-57)94(150)122-67(29-19-41-113-99(109)110)95(151)130-42-20-30-75(130)93(149)121-64(26-14-16-38-101)85(141)124-69(43-53(2)3)87(143)119-63(25-13-15-37-100)84(140)126-72(47-58-50-114-62-24-12-11-23-60(58)62)90(146)128-74(49-80(136)137)92(148)127-73(48-77(104)133)91(147)123-68(96(152)153)35-36-76(103)132/h8-12,21-24,31-34,50,53-55,61,63-75,81,114,131H,7,13-20,25-30,35-49,51-52,100-102H2,1-6H3,(H2,103,132)(H2,104,133)(H,115,134)(H,116,138)(H,117,135)(H,118,139)(H,119,143)(H,120,144)(H,121,149)(H,122,150)(H,123,147)(H,124,141)(H,125,145)(H,126,140)(H,127,148)(H,128,146)(H,129,142)(H,136,137)(H,152,153)(H4,105,106,111)(H4,107,108,112)(H4,109,110,113)/t55-,61-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,81-/m0/s1. InChI key: JMNJYGMAUMANNW-FIXZTSJVSA-N. Gene Information: human ... OPRK1(4986)
mouse ... Oprd1(18386)
pig ... PDYN(445529)
rat ... Oprd1(24613). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).