Duocarmycin DM free base

Duocarmycin DM free base, a DNA minor-groove alkylator , is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activityIn VitroThe Duocarmycins and CC-1065 are members of a class of DNA minor groove, AT-sequence selective, and adenine-N3 alkylating agents, isolated from Streptomyces sp. that exhibit extremely potent cytotoxicity against the growth of cancer cells grown in culture. Duocarmycin shows cytotoxicity to several human cancer cells, with IC 50 of 22, 13.8, 3.87, 15.4, and 7.31 pM for HT-29, CL1-5, Caski, EJ, and LS174T, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Daunorubicins/Doxorubicins

Specification: Moligand™, ≥95%

Molecular Formula: C26H26ClN3O3

Molecular Weight: 463.96

PubChem CID: 56675231

Isomeric SMILES: CN(C)CCOC1=CC2=C(C=C1)NC(=C2)C(=O)N3C[C@H](C4=C3C=C(C5=CC=CC=C54)O)CCl