Valproic acid

The orally bioavailable, valyl ester prodrug of ganciclovir, an antiviral agent that inhibits viral DNA synthesis (IC₅₀ = 0.95 &muM) by targeting the CMV polymerase used for the treatment of HIV associated retinitis and for the

A 21:5 &omega-3 fatty acid present in trace amounts in the green alga B. pennata and in fish oils can be used to study the significance of the position of the double bonds in &omega-3 fatty acids rapidly inactivates PGHS (COX).

2-Pyrimidin-2-yl-propionic acid is a synthetic intermediate useful for pharmaceutical synthesis.

An internal standard for the quantification of CEP-Lysine by GC- or LC-MS.

An agonist of the bile acid receptor TGR5 (EC50 = 1 &microM) and blocks fatty liver development in cells and mice given ethanol reduces NF-&kappaB signaling and expression of miR-33 in LPS-treated macrophages, increasing levels of ABCA1 inhibits

An ATP-competitive, allosteric inhibitor of IRE1&alpha RNase kinase activity (IC₅₀ = 0.6 &microM) prevents IRE1&alpha oligomerization and promotes cell survival under ER stress in rat models of retinal degeneration and diabetes.

An RSV inhibitor that demonstrates antiviral activity with an EC₅₀ value of 1.4 nM interferes directly with RSV fusion (EC₅₀ = 5.4 nM), binding to the viral F protein.

A physiologically active metabolite of losartan a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.

Phytanic acid is a saturated 20-carbon branched-chain fatty acid which can only be derived from dietary sources. In cases of peroxisomal disorders, elevated levels of phytanic acid have been observed, and this is linked to diseases such as infantile

1-Oleoyl lysophosphatidic acid is a species of LPA containing oleic acid at the sn-1 position. Phosphatidic acid is produced either directly through the action of PLD or through a two step process involving liberation of DAG by PLC followed by

A physiologically active metabolite of losartan a potent AT1 antagonist (Kis = 0.57 and 0.67 nM for rat and human forms, respectively), producing a depressor response and vasodilatation.

An agonist of the bile acid receptor TGR5 (EC50 = 1 &microM) and blocks fatty liver development in cells and mice given ethanol reduces NF-&kappaB signaling and expression of miR-33 in LPS-treated macrophages, increasing levels of ABCA1 inhibits