Mephobarbital or methylphenobarbital

A reversible, cell-permeable inhibitor of JARID1 family demethylases (IC₅₀s = 6, 3, 4.9, and 28 &microM for JARID1A, JARID1B, JARID1C, and JARID1D, respectively) increases trimethylation of H3K4 in HeLa cells and blocks the

A hybrid molecule patterned after N-arachidonoyl serotonin effects of docosahexaenoyl serotonin are unknown.

A hybrid molecule patterned after N-arachidonoyl serotonin inhibits capsaicin-induced TRPV1 channel activation (IC₅₀ = 2.57 &muM) without blocking FAAH-mediated hydrolysis of arachidonoyl ethanolamine (IC₅₀ &gt 50 &muM).

A potent inhibitor of VEGFR1, 2, and 3 (IC50s = 5, 1, and 3 nM, respectively) also potently inhibits a variety of other receptor and non-receptor tyrosine kinases blocks tubule formation by HUVECs in vitro and prevents angiogenesis as well as

A non-lipid inhibitor of cellular ceramidase activity (IC50 = 28 &muM in a cell-based assay) induces the accumulation of endogenous ceramide species and decreases intracellular levels of sphingosine and S1P inhibits cell proliferation of ovarian

A centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat) that also inhibits dopamine uptake through the dopamine transporter (Ki = 160 nM) used in the management of Parkinson&rsquos disease symptoms to address

The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable,

A natural 20:0 ceramide that is abundant in the brain synthesized de novo by ceramide synthases 1 and 2.

2-Hydroxymyristic acid is an inhibitor of protein myristoylation requiring about 0.5 mM concentration for full inhibition of acylation.

The kinesin-like spindle protein Eg5 (also known as kinesin-5, kinesin family protein 11, or Kif11) is a motor protein that is essential for establishing a bipolar spindle during mitosis both in normal and tumor cells. Ispinesib is a cell-permeable,

A centrally acting M1 muscarinic acetylcholine receptor antagonist (Ki = 0.59 nM in rat) that also inhibits dopamine uptake through the dopamine transporter (Ki = 160 nM) used in the management of Parkinson&rsquos disease symptoms to address

A non-lipid inhibitor of cellular ceramidase activity (IC50 = 28 &muM in a cell-based assay) induces the accumulation of endogenous ceramide species and decreases intracellular levels of sphingosine and S1P inhibits cell proliferation of ovarian