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dpq (c15-1210-462)

DPQ >=98% (HPLC) SOLID (C005B-013685)

Catalog No.
C005B-013685
Manufacturer No.
D5314-1MG
Manufacturer Name
Sigma-Aldrich
Quantity
1
Unit of Measure
MG

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Application DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation. Biochem/physiol Actions

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Application

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

DPQ is a very potent poly(ADP-ribose) polymerase (PARP) inhibitor.

Molecular Weight: 302.41. Empirical Formula: C18H26N2O2. biological source: synthetic (organic). Quality Level: 200. Assay: ≥. 98% (HPLC). form: solid. mp: 107-109  . °C. solubility: DMSO: 1 . mg/mL, clear, colorless to faintly yellow. storage temp.: 2-8°C. InChI: 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21). InChI key: RVOUDNBEIXGHJY-UHFFFAOYSA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.
UPC:
12141903
Condition:
New
HazmatClass:
No
MPN:
D5314-1MG
CAS:
129075-73-6

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