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dph (c15-1725-522)

DPH (C005B-313681)

Catalog No.
C005B-313681
Manufacturer No.
SML0202-25MG
Manufacturer Name
Sigma-Aldrich
Quantity
25
Unit of Measure
MG

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Application DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies. Biochem/physiol Actions DPH binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase.

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Application

DPH may be used in c-Abl tyrosine kinase-mediated cell signaling studies.

Biochem/physiol Actions

DPH binds and alters the conformation of the myristoyl binding site of c-Abl tyrosine kinase. It exhibits potent enzymatic and cellular activity that stimulates the activation of c-Abl.

DPH is a potent cell permeable c-Abl activator. DPH binds to the myristoyl binding site and leads to activation of c-Abl kinase activity. The compound stimulates the phosphorylation of c-Abl and its downstream substrate Crk.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Abl page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

UPC:
51201805
Condition:
New
HazmatClass:
No
MPN:
SML0202-25MG
CAS:
484049-04-9

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