DPEG(R)24-BIOTIN ACID

Features and Benefits

dPEG₂₄ biotin acid consists of a biotin molecule conjugated to a single molecular weight polyethylene glycol chain of discrete length (dPEG). The dPEG chain is 76 atoms (90.1 Å) long. The distal end of the dPEG chain terminates with a propionic acid group. The terminal acid is available for direct conjugation to free amines or functionalization as an active ester. Amphiphilic dPEG₂₄ biotin acid can be dissolved both in water or aqueous buffer and in organic solvent. It does not cause aggregation or precipitation of biomolecules. Using 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) chemistry, dPEG₂₄ biotin acid can be coupled directly to free primary amines in aqueous media. These free amines can be on a protein, peptide, or the treated surface of a nanoparticle. Moreover, the acid moiety can be functionalized with other reactive groups for coupling directly to surfaces such as glass, gold, or magnetic nanoparticles. The linker length of dPEG₂₄ biotin acid is much longer than the linker lengths of LC-biotin and of LC-LC-biotin and is a monodisperse equivalent of a PEG₁₀₀₀. The performance characteristics of dPEG₂₄-biotin acid are quite superior to both LC-biotin and LC-LC-biotin.

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Legal Information

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign