DMT-DG(IB) AMIDITE 5G SINGLE (C005B-090664)

General description

Proligo′s DNA phosphoramidites lead to high-yield and high-quality oligonucleotides due to their high coupling efficiency. The deprotection step of automated oligonucleotide synthesis is integral to synthesis time and final product quality. Exocyclic amine functions are protected by a benzoyl group (dA(bz) and dC(bz)) or isobutyryl group (dG(ib))Key features of DNA phosphoramidites :

• Recommended cleavage and deprotection conditions are 8 hours at 55 °Cor 24 hours at room temperature using concentrated ammonia solution, for standard base-protected oligonucleotides
• The high coupling efficiency of Proligo′s DNA phosphoramidites leads to high-yield and high-quality oligonucleotides

The product belongs to ABI^™ synthesizers.

Legal Information

ABI is a trademark of Applera Corporation or its subsidiaries in the US and/or certain other countries

OligoPilot is a registered trademark of Cytiva

ÄKTA is a registered trademark of Cytiva

Molecular Weight: 839.92. Empirical Formula: C₄₄H₅₄N₇O₈P. biological source: non-animal source (no BSE/TSE risk). Quality Level: 200. type: for DNA synthesis. product line: Proligo Reagents. Assay: ≥. 99% (³¹P-NMR), ≥. 99.0% (reversed phase HPLC). form: powder or granules. technique(s): oligo synthesis: suitable. impurities: ≤. 0.3 . wt. % water content (Karl Fischer). color: white to off-white. λ: conforms (UV/VIS Identity). compatibility: configured for (ÄKTA^®. and OligoPilot^®. ), configured for ABI. nucleoside profile: base: deoxyguanosine
base protecting group: isobutyryl
2' protecting group: none
5' protecting group: DMT
deprotection: standard. storage temp.: 2-8°C. SMILES string: COc1ccc(cc1)C(OC[C@H]2O[C@H](C[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)n3cnc4C(: O)NC(NC(: O)C(C)C): Nc34)(c5ccccc5)c6ccc(OC)cc6. InChI: 1S/C44H54N7O8P/c1-28(2)41(52)48-43-47-40-39(42(53)49-43)46-27-50(40)38-25-36(59-60(57-24-12-23-45)51(29(3)4)30(5)6)37(58-38)26-56-44(31-13-10-9-11-14-31,32-15-19-34(54-7)20-16-32)33-17-21-35(55-8)22-18-33/h9-11,13-22,27-30,36-38H,12,24-26H2,1-8H3,(H2,47,48,49,52,53)/t36-,37+,38+,60?/m0/s1. InChI key: FDRMKYVTIFSDPR-MMROLVBFSA-N. Storage Class Code: 13 - Non Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.