DMT-2''O-TBDMS-RC(AC) AMIDITE SEPTUM (C005B-011486)

General description

DMT-2′O-TBDMS-rC(ac) Phosphoramidite belongs to the 2′O-TBDMS RNA Phosphoramidites.

Features and Benefits

• Industry standard 2′O-TBDMS protective group
• Consistent lot-to-lot purity and performance
• Compatible with deprotection methods based on methylamine or AMA
• Standard RNA phosphoramidites provide excellent coupling results when used with ETT or BTT as an activator; best results are obtained with Activator 42
• Capping with standard acetic anhydride capping reagent rather than with fast Deprotection Cap A
• Manufactured under a certified ISO 9001 quality system

Legal Information

OligoPilot is a registered trademark of Cytiva

ÄKTA is a registered trademark of Cytiva

Molecular Weight: 902.10. Empirical Formula: C₄₇H₆₄N₅O₉PSi. biological source: non-animal source (no BSE/TSE risk). Quality Level: 200. product line: Proligo Reagents. Assay: ≥. 99% (³¹P-NMR), ≥. 99.0% (reversed phase HPLC). form: powder. technique(s): oligo synthesis: suitable. impurities: ≤. 0.3% water content (Karl Fischer), ≤. 0.5% P(III) Impurities 100-169ppm (³¹P-NMR), ≤. 0.5% single Impurity (reversed phase HPLC), ≤. 3% residual Solvent content. color: white to off-white. λ: conforms (UV/VIS Identity). suitability: conforms to structure for H-NMR, conforms to structure for LC-MS. compatibility: configured for (ÄKTA^®. and OligoPilot^®. ). nucleoside profile: base: cytidine
base protecting group: acetyl
2' protecting group: TBDMS
5' protecting group: DMT
deprotection: fast/standard. storage temp.: −. 20°C. SMILES string: COc1ccc(cc1)C(OC[C@H]2O[C@H]([C@H](O[Si](C)(C)C(C)(C)C)[C@@H]2OP(OCCC#N)N(C(C)C)C(C)C)N3C: CC(NC(C): O): NC3: O)(c4ccccc4)c5ccc(OC)cc5. InChI: 1S/C47H64N5O9PSi/c1-32(2)52(33(3)4)62(58-30-16-28-48)60-42-40(59-44(43(42)61-63(11,12)46(6,7)8)51-29-27-41(49-34(5)53)50-45(51)54)31-57-47(35-17-14-13-15-18-35,36-19-23-38(55-9)24-20-36)37-21-25-39(56-10)26-22-37/h13-15,17-27,29,32-33,40,42-44H,16,30-31H2,1-12H3,(H,49,50,53,54)/t40-,42-,43-,44-,62?/m1/s1. InChI key: QKWKXYVKGFKODW-YOEDQOPESA-N. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.