DL-AP5 sodium salt (C007B-130897)

Potent and selective NMDA antagonist; sodium salt of DL-AP5Biological Activity：DL-AP5 Sodium salt is the sodium salt of DL-AP5 (Cat. No. 0105) and a racemic mixture of the D- and L-isomers of AP5, a selective NMDA receptor antagonist that competes with glutamate binding and is commonly used to inhibit NMDA-dependent synaptic plasticity. D-AP5 (Cat. No. 0106) is the more active isomer and displays approximately 52-fold higher potency than the L-isomer, L-AP5 (Cat. No. 0107). In vitro D-AP5 reduces NMDA-induced depolarization of cortical neurons, with no effect on the response to L-Quisqualic acid (Cat. No. 0188) or Kainic acid (Cat. No. 0222). Following spinal injection of D-AP5, NMDA-response is rapidly reduced, with no effect seen on spontaneously active neurons.DL mixture, D-isomer and L-isomer also available.

Specifications and Purity: ≥98%

Molecular Formula: C5H11NNaO5P

Molecular Weight: 219.11

PubChem CID: 52974251

Isomeric SMILES: C(CC(C(=O)O)N)CP(=O)(O)[O-].[Na+]

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