DL-ALPHA-DIFLUOROMETHYLORNITHINE HYDROCHLORIDE HYDRATE (C005B-058003)

General description

Difluoromethylornithine is a fluorinated ornithine analog, which acts as a rate-limiting enzyme of polyamine biosynthesis. It is used to treat female facial hirsutism and human African trypanosomiasis. Difluoromethylornithine functions as a chemopreventive and chemotherapeutic agent against neuroblastoma and colorectal cancer. It exhibits cytostatic effects on mammalian cells and tissues.

Application

DL-α-Difluoromethylornithine hydrochloride hydrate has been used to reduce the effects of arginine on cell proliferation. It has also been used to investigate the effect of bisphenol A (BPA) on the migration of an established ovine trophectoderm (oTr1) cell line.

Biochem/physiol Actions

Difluoromethylornithine (Eflornithine) inhibits polyamine biosynthesis by the selective, irreversible inhibition of ornithine decarboxylase (ODC). A chemoprotective agent that blocks angiogenesis.

Molecular Weight: 182.17 (anhydrous free base basis). Empirical Formula: C₆H₁₂F₂N₂O₂ · xHCl · yH₂O. Quality Level: 100. Assay: ≥. 97% (NMR). form: solid. color: white. solubility: DMSO: >. 10 . mg/mL, H₂O: >. 10 . mg/mL. SMILES string: O.Cl.NCCCC(N)(C(F)F)C(O): O. InChI: 1S/C6H12F2N2O2.ClH.H2O/c7-4(8)6(10,5(11)12)2-1-3-9. . /h4H,1-3,9-10H2,(H,11,12). 1H. 1H2. InChI key: FJPAMFNRCFEGSD-UHFFFAOYSA-N. Gene Information: human ... ODC1(4953). Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Gloves, type N95 (US).