DHED (C005B-311816)

Catalog No.: C005B-311816
Manufacturer No.: SML1642-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 25
Unit of Measure: MG

Application DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′:s disease (PD)-like motor syndrome. Biochem/physiol Actions DHED (10β:,17β:-dihydroxyestra-1,4-dien-3-one) is an inactive

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Description
Specifications

Application

DHED has been used to induce an increase of estrogen levels in 3K transgenic mice with Parkinson′s disease (PD)-like motor syndrome.

Biochem/physiol Actions

DHED (10β,17β-dihydroxyestra-1,4-dien-3-one) is an inactive prodrug that selectively produces estrogen solely in the brain. DHED is converted to 17β-estradiol in the brain by an enzyme only expressed in the CNS, but is inert in the rest of the body. DHED was found to provide neuroprotection in a rat stroke model and reversed neurological symptoms of estrogen deprivation such as memory problems in female rats lacking ovaries.

DHED is a substrate for nicotinamide adenine dinucleotide phosphate (NADPH)-dependent dehydrogenase/reductase. Its expression in the brain is correlated to neuroprotection functionality.

UPC:: 41113631
Condition:: New
HazmatClass:: No
MPN:: SML1642-25MG
CAS:: 549-02-0

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