Dacarbazine (NSC-45388)

InformationDacarbazine (NSC-45388) Dacarbazine (NSC-45388, DTIC-Dome, Imidazole Carboxamide) is a triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA functiIn vitroTreatment of Dacarbazine sensitizes melanomas to lysis of peptide-specific CTL and it is is mediated through Fas-independent pathway.In vivoTreatment of combination of Axitinib and DTIC demonstrates significant antitumor activity against melanoma flank xenografts, reduces tumor cell proliferation and decreases the area of tumor necrosis and increases apoptosis. It also reduces meta-tasis-related factors and prolongs lifespan in mice.Cell Datacell lines：Concentrations：20 μMIncubation Time：48 hPowder Purity:≥99%.

Specifications and Purity: 10mM in DMSO

Molecular Formula: C6H10N6O

Molecular Weight: 182.18