CYTOSINE-B-D-ARABINOFURANOSIDE HYDROCHLORIDE (C005B-057829)

Application

Cytosine β-D-arabinofuranoside hydrochloride has been used in fetal bovine serum supplemented Dulbecco′s modified eagle medium (FBS-DMEM) and B27/neurobasal-A medium to inhibit the growth of glial cells. It has also been used to inhibit astrocyte proliferation in embryonic spinal cord neurons.

Biochem/physiol Actions

Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.

Molecular Weight: 279.68. Empirical Formula: C₉H₁₃N₃O₅ · HCl. biological source: synthetic (inorganic). Quality Level: 200. Assay: ≥. 99% (HPLC). form: crystalline. mp: 197-198 . °C (lit.). storage temp.: 2-8°C. SMILES string: Cl[H].NC1: NC(: O)N(C: C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O. InChI: 1S/C9H13N3O5.ClH/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8. /h1-2,4,6-8,13-15H,3H2,(H2,10,11,16). 1H/t4-,6-,7+,8-. /m1./s1. InChI key: KCURWTAZOZXKSJ-JBMRGDGGSA-N. Gene Information: human ... POLA1(5422), POLA2(23649), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558). Pictograms: GHS07,GHS08. Signal Word: Warning. Hazard Statements: H317 - H319 - H341 - H361. Precautionary Statements: P201 - P280 - P302 + P352 - P305 + P351 + P338 - P308 + P313. Hazard Classifications: Eye Irrit. 2 - Muta. 2 - Repr. 2 - Skin Sens. 1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable.