CYTOSINE BETA-D-ARABINOFURANOSIDE CRYSTALLINE >=90% (HPLC) (C005B-018898)

Biochem/physiol Actions

Ara-C incorporates into DNA and inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation; does not inhibit RNA synthesis. Anti-leukemia agent.

Features and Benefits

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Molecular Weight: 243.22. Empirical Formula: C₉H₁₃N₃O₅. Quality Level: 200. Assay: ≥. 90% (HPLC). form: crystalline. storage temp.: 2-8°C. SMILES string: NC1: NC(: O)N(C: C1)[C@@H]2O[C@H](CO)[C@@H](O)[C@@H]2O. InChI: 1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1. InChI key: UHDGCWIWMRVCDJ-CCXZUQQUSA-N. Gene Information: human ... POLA1(5422), POLA2(23649), POLB(5423), POLD1(5424), POLD2(5425), POLD3(10714), POLD4(57804), POLE(5426), POLE2(5427), POLE3(54107), PRIM1(5557), PRIM2(5558)
mouse ... Cda(72269). Pictograms: GHS07,GHS08. Signal Word: Warning. Hazard Statements: H317 - H361fd. Precautionary Statements: P202 - P261 - P272 - P280 - P302 + P352 - P308 + P313. Hazard Classifications: Repr. 2 - Skin Sens. 1. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges.