CYCLOPROPYLMAGNESIUM BROMIDE 0.5 M IN THF (C005B-026651)

Application

Cyclopropylmagnesium bromide solution has been used in Grignard reaction that finds application as the key step in the preparation of aminopropylindenes, a chemotype of oxidosqualene cyclase (OSC) inhibitors from Grundmann′s ketone. It can react with trimethylborate to form cyclopropylboronic acid, which can undergo Suzuki-type coupling reactions with different aryl, and heteroaryl bromides to form the cyclopropyl adducts.

Molecular Weight: 145.28. Empirical Formula: C₃H₅BrMg. reaction suitability: reaction type: Grignard Reaction. Quality Level: 100. concentration: 0.5 . M in THF. bp: 65 . °C. density: 0.968 . g/mL . at 25 . °C. storage temp.: 2-8°C. SMILES string: Br[Mg]C1CC1. InChI: 1S/C3H5.BrH.Mg/c1-2-3-1. . /h1H,2-3H2. 1H. /q. . +1/p-1. InChI key: QUPLLJGAJVXXBW-UHFFFAOYSA-M. Pictograms: GHS02,GHS05,GHS07,GHS08. Signal Word: Danger. Hazard Statements: H225 - H261 - H302 - H314 - H335 - H336 - H351. Precautionary Statements: P210 - P231 + P232 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B - Water-react 2. Supp Hazards: EUH019. Storage Class Code: 4.3 - Hazardous materials, which set free flammable gases upon contact with water. WGK: WGK 3. Flash Point(F): 1.0 °F - closed cup. Flash Point(C): -17.22 °C - closed cup.