General description

Cycloheximide is an antibiotic having significant antifungal properties. It is produced by streptomycin-producing strains of Streptomyces griseus and acts by inhibiting protein synthesis. Its main biological activity is translation inhibition in eukaryotes resulting in cell growth arrest and cell death. It is used as a fungicide.
As per Regulation (EC) No 1107/2009, repealing the directive 91/414, cycloheximide is not approved for use in the European Union (EU).

Application

Cycloheximide may find the following uses:

To evaluate the antifungal efficacy and safety of cycloheximide as a supplement in Optisol-GS
To study the effect of cycloheximide on leaf-cutting ant workers
To study the effect of streptomycin, cycloheximide, fungizone, captan, carbofuran, cygon, and pentachloronitrobenzene on soil microorganisms
To study the fungal control of nitrous oxide production in a semiarid grassland
To study the activity and degradation of streptomycin and cycloheximide in soil

Biochem/physiol Actions

Mode of Action: Translation inhibition in eukaryotes resulting in cell growth arrest and cell death. CHX is widely used for the selection of CHX-resistant strains of yeast and fungi, controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression, and apoptosis induction or facilitation of apoptosis induction by death receptors.

Activity Spectrum: Active against yeast and fungi like Candida, Aspergillus, Saccharomyces, Penicillium

Legal Information

PESTANAL is a registered trademark of Sigma-Aldrich International GmbH

Molecular Weight: 281.35. Empirical Formula: C₁₅H₂₃NO₄. grade: analytical standard. Quality Level: 100. description: mixture of stereo isomers. product line: PESTANAL^®.. Assay: ≥. 95% (HPLC). shelf life: limited shelf life, expiry date on the label. technique(s): HPLC: suitable, gas chromatography (GC): suitable. solubility: H₂O: slightly soluble. antibiotic activity spectrum: fungi. application(s): agriculture
cleaning products
cosmetics
environmental
food and beverages
personal care. format: neat. Mode of action: protein synthesis | interferes. storage temp.: −. 20Â°C. SMILES string: [H][C@]1(C[C@@H](C)C[C@H](C)C1: O)[C@H](O)CC2CC(: O)NC(: O)C2. InChI: 1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19)/t8-,9-,11-,12+/m0/s1. InChI key: YPHMISFOHDHNIV-FSZOTQKASA-N. Pictograms: GHS06,GHS08,GHS09. Signal Word: Danger. Hazard Statements: H300 - H341 - H360D - H411. Precautionary Statements: P202 - P264 - P270 - P273 - P280 - P301 + P310. Hazard Classifications: Acute Tox. 2 Oral - Aquatic Chronic 2 - Muta. 2 - Repr. 1B. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges.