CUCURBITACIN I HYDRATE >=95% (HPLC) SOLID

Biochem/physiol Actions

Cucurbitacin I (JSI-124) is a novel selective inhibitor of the janus kinase 2/signal transducer and activator of transcription 3 (JAK2/STAT3) signaling pathway with anti-proliferative and anti-tumor properties.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the JAKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Molecular Weight: 514.65 (anhydrous basis). Empirical Formula: C₃₀H₄₂O₇ · xH₂O. Quality Level: 100. Assay: ≥. 95% (HPLC). form: solid. color: white to off-white. solubility: DMSO: >. 5 . mg/mL. storage temp.: −. 20°C. SMILES string: O.CC(C)(O)\C: C\C(: O)[C@](C)(O)[C@H]1[C@H](O)C[C@@]2(C)[C@@H]3CC: C4[C@@H](C: C(O)C(: O)C4(C)C)[C@]3(C)C(: O)C[C@]12C. InChI: 1S/C30H42O7.H2O/c1-25(2,36)12-11-21(33)30(8,37)23-19(32)14-27(5)20-10-9-16-17(13-18(31)24(35)26(16,3)4)29(20,7)22(34)15-28(23,27)6. /h9,11-13,17,19-20,23,31-32,36-37H,10,14-15H2,1-8H3. 1H2/b12-11+. /t17-,19-,20+,23+,27+,28-,29+,30+. /m1./s1. InChI key: ZKDSPEWKSJCXQE-NEBRQAMTSA-N. Pictograms: GHS06. Signal Word: Danger. Hazard Statements: H300. Precautionary Statements: P264 - P270 - P301 + P310 - P405 - P501. Hazard Classifications: Acute Tox. 1 Oral. Storage Class Code: 6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials. WGK: WGK 3. Flash Point(F): Not applicable. Flash Point(C): Not applicable. Personal Protective Equipment: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges.