CP-681301 (C005B-308865)

Catalog No.: C005B-308865
Manufacturer No.: SML3512-25MG
Manufacturer Name: Sigma-Aldrich
Quantity: 1
Unit of Measure: EA

Biochem/physiol Actions CP-681301 is a potent, ATP-competitive cyclin-dependent kinase Cdk5 inhibitor (Ki = 13.7 nM: 2.

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Description
Specifications

Biochem/physiol Actions

CP-681301 is a potent, ATP-competitive cyclin-dependent kinase Cdk5 inhibitor (Ki = 13.7 nM; 2.8-/40-fold selectivity over Cdk2/GSK-3β) that blocks Cdk5 substrates phosphorylation in cultures (tau pS235 IC50 = 513 nM in CHO p25/CDK5/tau transfectants; IC50 ~500 nM against 48-h 10 µM oligomeric Aβ42-stimulated APP pT668 in murine embryonic neurons) and reverses the upregulated tau pS235 level in Cdk5 activator p25-overexpressing transgenic neonatal mice in vivo (5.8 mg/kg s.c.; 6 hrs). CP-681301 selectively inhibits Cdk5-dependent proliferation of human medullary thyroid carcinoma (MTC), but not normal human fibroblasts in cultures (5 µM, 48 hrs).

UPC:: 42181603
Condition:: New
HazmatClass:: No
MPN:: SML3512-25MG
CAS:: 865317-32-4

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