CP-673451 (C005B-309110)

Catalog No.: C005B-309110
Manufacturer No.: SML3368-10MG
Manufacturer Name: Sigma-Aldrich
Quantity: 10
Unit of Measure: MG

Biochem/physiol Actions CP-673451 is an ATP-competitive, potent and selective platelet-derived growth factor receptor inhibitor (PDGFR1 (β:)/PDGFR2 (α:) IC50 = 1/10 nM with 10 μ:M ATP: IC50 = 252 nM/c-kit, 450 nM/VEGFR-1/2:

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Description
Specifications

Biochem/physiol Actions

CP-673451 is an ATP-competitive, potent and selective platelet-derived growth factor receptor inhibitor (PDGFR1 (β)/PDGFR2 (α) IC50 = 1/10 nM with 10 μM ATP; IC50 = 252 nM/c-kit, 450 nM/VEGFR-1/2; >450-fold reduced potency toward other angiogenic receptors and non-receptor kinases). CP-673451 potently inhibits PDGF-BB-induced receptor phosphorylation (IC50 = 6.4 nM; PDGFR1 transfectant) and effectively suppress human cancer xenografts-derived tumor in mice in vivo (ED50 ≤33 mg/kg via b.i.d. or q.d. p.o.) by inhibiting PDGFR phosphorylation and angiogenesis in tumor tissues.

UPC:: 42181601
Condition:: New
HazmatClass:: No
MPN:: SML3368-10MG
CAS:: 343787-29-1

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