COX-1 Inhibitor II

COX-1 Inhibitor II is a cell-permeable benzenesulfonamide compound that targets the catalytic site of Cox (cyclooxygenase). COX-1 Inhibitor II inhibits Cox-1 (IC|50|of 3.2 μM) more selectively than Cox-2 (IC|50|of > 100 μM). Much like Aspirin , COX-1 Inhibitor II has shown similar|in vivo|analgesic activity, yet unlike Aspirin and Indomethacin, COX-1 Inhibitor II does not induce gastric disturbance. The compound was revealed to inhibit PCA response in addition to Cox-2 expression and to exert anti-inflammatory effects by suppressing phosphorylation of ERK.

Specifications and Purity: ≥95%

Molecular Formula: C13H13ClN2O2S

Molecular Weight: 296.8

PubChem CID: 16126699

Isomeric SMILES: CN(C1=CC=C(C=C1)Cl)S(=O)(=O)C2=CC=C(C=C2)N

Related Documents: https://aladdin-for-icloud-store.oss-cn-hangzhou.aliyuncs.com/aladdinsci/pdp/sds/1/C336912-SCI_c74b4a43afb1bae49efcb03a163a081b.pdf