(-)-COTININE >/=98% (C005B-043935)

General description

Cotinine is an alkaloid extracted from tobacco leaves. It can cross the blood-brain barrier. Cotinine is used to treat Alzheimer′s disease (AD), schizophrenia and post-traumatic stress disorder (PTSD).

Application

Cotinine has been used:

• for oxygen-glucose deprivation (OGD) studies to model ischemic stroke
• as a standard to determine serum cotinine measurements using liquid chromatography with tandem mass spectrometry (LC-MS/MS)
• to evaluate the adverse developmental potential of cotinine
• to assess cognitive behavior in mice

Biochem/physiol Actions

Major metabolite of nicotine in humans.

Molecular Weight: 176.22. Empirical Formula: C₁₀H₁₂N₂O. Quality Level: 200. Assay: ≥. 98%. form: crystals. bp: 250 . °C/150 . mmHg (lit.). mp: 40-42 . °C (lit.). storage temp.: 2-8°C. SMILES string: CN1[C@@H](CCC1: O)c2cccnc2. InChI: 1S/C10H12N2O/c1-12-9(4-5-10(12)13)8-3-2-6-11-7-8/h2-3,6-7,9H,4-5H2,1H3/t9-/m0/s1. InChI key: UIKROCXWUNQSPJ-VIFPVBQESA-N. Gene Information: human ... CYP1A2(1544), CYP2A6(1548)
mouse ... Cyp2a5(13087). Pictograms: GHS07. Signal Word: Warning. Hazard Statements: H302 - H315 - H319 - H335. Precautionary Statements: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338. Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3. Target Organs: Respiratory system. Storage Class Code: 11 - Combustible Solids. WGK: WGK 3. Flash Point(F): 230.0 °F - closed cup. Flash Point(C): 110 °C - closed cup. Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves.